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GLPFlo Quality Assurance

Cold-Chain Shipping & Temperature Stability Study

Published June 2026 · Reviewed annually · Verified by an independent third-party laboratory

What you need to know

A warm/hot vial on arrival is not a defective vial.

While your medication should be refrigerated for long-term storage, it is normal for temperatures to fluctuate during shipping. The refrigeration instructions are intended to maximize stability throughout the product's shelf life, but they do not mean the medication becomes ineffective or unsafe if it temporarily warms during transit.

7 days

Stable in transit

≤ 104 °F

Peak transit temp tested

USP <797>

Sterile compounding standard

Our compounded GLP-1 medications are shipped using packaging that has been evaluated under real-world shipping conditions. Independent third-party stability testing has demonstrated that the medication remains safe, sterile, and effective during transit for up to 7 days, even when exposed to temperatures as high as 104°F (40°C). This testing is designed to simulate the temperature fluctuations that can occur during transportation.

When assessing a temperature-sensitive medication, it is important to understand that stability is determined by both temperature and duration of exposure. Brief temperature excursions during shipping are different from prolonged storage at elevated temperatures. The medication has been tested to ensure that these temporary shipping conditions do not negatively impact its quality, potency, or sterility.

Upon delivery, the medication may feel cool, room temperature, slightly warm or hot depending on weather conditions, transit times, and the time elapsed since delivery. This alone does not indicate that the medication has been compromised. In many cases, the cold packs included in the shipment may no longer be frozen upon arrival, which is expected and does not mean the medication is unsafe to use.

Once received, you should place the medication in the refrigerator as soon as possible and store it according to the instructions provided. Refrigeration helps maintain the medication's quality for the remainder of its beyond-use date.

Please contact us before using your medication if:

  • The shipment was significantly delayed beyond the expected transit time.
  • The package appears damaged or tampered with.
  • The vial is cracked, leaking, discolored, cloudy (if it should be clear), or contains visible particles.
  • You have concerns about unusual shipping circumstances or extended exposure to extreme temperatures after delivery.

Our goal is to ensure every patient receives medication that meets strict quality standards. The shipping process, packaging, and stability testing have been designed specifically to protect the medication during normal transit conditions, including temporary temperature fluctuations that may occur during delivery.

Perfectly normal — use the vial

  • Vial feels hot, warm or room-temperature to the touch on arrival
  • Cold packs are partially or fully melted
  • Vial is clear and free of particulate, the seal is intact, and the box was not visibly damaged in transit
  • Solution has a slight, faint color shift between batches (compounding-pharmacy lot variance is normal)

Contact us within 24 hours

  • Glass is visibly cracked or chipped
  • Vial cap or rubber stopper is broken, lifted, or not properly seated
  • Solution is cloudy, has visible particles, or has clearly changed colour from its baseline
  • Vial is leaking
  • The vial arrived completely frozen solid (freezing can damage peptide medications)
  • The carrier confirms the package sat at >104 °F / 40 °C for more than ~7 consecutive days

Free no-charge replacement when reported within 24 hours of delivery. Photo of the defect speeds up replacement.

Per-pharmacy stability studies

Download the independent third-party shipping stability study for each of our compounding pharmacy partners.

Polomar Specialty Pharmacy

Study available on request — email hello@glpflo.org

Sources & published studies

Independent, third-party evidence backing every claim on this page. All links open in a new tab.

Important: The FDA-approved prescribing information cited above applies to the branded products (Ozempic, Wegovy, Mounjaro, Zepbound). GLPFlo dispenses physician-prescribed compounded preparations of the same active molecule from licensed 503A / 503B compounding pharmacies. Our external third-party stability assay confirms equivalent thermal behavior, but the branded labels are cited as the strongest publicly-verifiable evidence that the molecule itself is robust at room temperature.

Refrigerate when possible

36 – 46 °F (2 – 8 °C) extends vial life to the printed BUD on your pharmacy label.

Never freeze the vial

Freezing is the one excursion that can damage peptide medications. Discard and contact us if it arrives frozen solid.

For the complete report including raw assay data, lab identifiers, and methodology, download the per-pharmacy PDFs above. Clinical questions: prescribing@glpflo.org. Quality / shipping concerns: hello@glpflo.org.

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